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Pancreatic Research Activities at the MGH

Team MGH at the Lustgarten Pancreatic Cancer Walk
Joan C. Wargo
The Lustgarten Foundation
Clinical Activities at the MGH
Pancreatic Research Activities at the MGH

Under the guidance of Andrew L. Warshaw, MD, Carlos Fernandez-del Castillo, MD, and Sarah P. Thayer, MD, PhD, the Center for Pancreatic Research and the Pancreatic Biology Research Laboratory has been active since 1983.
The focus of the lab is pancreatic disease, specifically, the pathogenesis of acute pancreatitis and pancreatic carcinogenesis.  The lab strives to understand the molecular determinants that may be critical in the biological behavior of pancreatic adenocarcinoma.
Recent work includes:
1. Sonic Hedgehog (Shh) Links Altered Developmental Programs to Pancreatic Neoplasia: Shh plays a early and critical role in the development of pancreatic ductal malignancy.
2. Preclinical Investigation into the Effects of Shh Pathway Agonist and Antagonists on the Biologic Behavior of Pancreatic Cancer: To determine if small molecule antagonists that inhibit the Hh pathway will have any clinically signfiicnat impact on the biologic behavior of pancreatic cancer.
More information on the studies being conducted at the Pancreatic Biology Research Laboratory can be found at:


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