Under the guidance of Andrew L. Warshaw, MD, Carlos Fernandez-del Castillo,
MD, and Sarah P. Thayer, MD, PhD, the Center for Pancreatic Research and the Pancreatic Biology Research Laboratory has
been active since 1983.
The focus of the lab is pancreatic disease, specifically, the pathogenesis
of acute pancreatitis and pancreatic carcinogenesis. The lab strives to understand the molecular determinants that
may be critical in the biological behavior of pancreatic adenocarcinoma.
Recent work includes:
1. Sonic Hedgehog (Shh) Links Altered Developmental Programs to Pancreatic Neoplasia: Shh plays a
early and critical role in the development of pancreatic ductal malignancy.
2. Preclinical Investigation into the Effects of Shh Pathway Agonist and
Antagonists on the Biologic Behavior of Pancreatic Cancer: To determine if small molecule antagonists that inhibit the
Hh pathway will have any clinically signfiicnat impact on the biologic behavior of pancreatic cancer.